
2025
Matsuda Y, Ishizaki T, Uto T, Onoda I, Wong RW, Takahashi K, Hirata E, Kuroda K. Dual-Functionalized Zwitterionic Polymers for Cell Cryopreservation. Langmuir. online ahead of print, 2025.
2024
Taniguchi K, Sugihara K, Miura T, Hoshi D, Kohno S, Takahashi C, Hirata E, Kiyokawa E. Cholesterol synthesis is essential for the growth of liver metastasis-prone colorectal cancer cells. Cancer Science. 115(11):3817-3828, 2024.
Giangreco G, Rullan A, Naito Y, Biswas D, Liu YH, Hooper S, Nenclares P, Bhide S, CheangM, Chakravarty P, Hirata E, Swanton C, Melcher A, Harrington K, Sahai E. Cancer cell-fibroblast crosstalk via HB-EGF/EGFR/MEK signaling promotes expression of macrophage chemo-attractants in squamous cell carcinoma. iScience. 3;27(9):110635, 2024.
Mizutani R, Hirata E*. Intracardiac Injection Mouse Model to Study Cancer Cell Dormancy in Brain Metastasis. Methods in Molecular Biology. 2811:113-122, 2024. (*corresponding author)
Ishibashi K, Hirata E*. Multifaceted interactions between cancer cells and glial cells in brain metastasis. Cancer Science. 115(9):2871-2878, 2024. (*corresponding author)
Kondo N, Kinouchi T, Natsumeda M, Matsuzaki J, Hirata E, Sakurai Y, Okada M, Suzuki M. Profile of miRNAs in small extracellular vesicles released from glioblastoma cells treated by boron neutron capture therapy. Journal of Neuro-Oncology. 168(1):91-97, 2024.
Ishizaki T, Tanaka D, Ishibashi K, Takahashi K, Hirata E, Kuroda K. Cell damage mechanisms during cryopreservation in a zwitterion solution and its alleviation by DMSO. Journal of Physical Chemistry B. 128(16):3904-3909, 2024
Kato Y, Uto T, Ishizaki T, Tanaka D, Ishibashi K, Matsuda Y, Onoda I, Kobayashi A, Hazawa M, Wong RW, Takahashi K, Hirata E, Kuroda K. Optimization of Zwitterionic Polymers for Cell Cryopreservation. Macromolecular bioscience. e2300499, 2024.
Ishibashi K, Ichinose T, Kadokawa R, Mizutani R, Iwabuchi S, Togi S, Ura H, Tange S, Shinjo K, Nakayama J, Nanjo S, Niida Y, Kondo Y, Hashimoto S, Sahai E, Yano S, Nakada M, Hirata E*. Astrocyte-induced mGluR1 activates human lung cancer brain metastasis via glutamate-dependent stabilization of EGFR. Developmental Cell. 59(5):1-16, 2024. (*corresponding author)
2023
Kato Y, Matsuda Y, Uto T, Tanaka D, Ishibashi K, Ishizaki T, Ohta A, Kobayashi A, Hazawa M, Wong RW, Ninomiya K, Takahashi K, Hirata E, Kuroda K. Cell-compatible isotonic freezing media enabled by thermo-responsive osmolyte-adsorption/exclusion polymer matrices. Communications Chemistry. 6:260, 2023.
Tange S, Hirano T, Idogawa M, Hirata E, Imoto I, Tokino T. MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway. BMC Cancer. 23(1):85, 2023.
Ishizaki T, Takeuchi Y, Ishibashi K, Gotoh N, Hirata E*, Kuroda K*. Cryopreservation of tissues by slow-freezing using an emerging zwitterionic cryoprotectant. Scientific Reports. 13(1):37, 2023. (*co-corresponding author)
2022
Komori T, Kato Y, Ishibashi K, Ninomiya K, Wada N, Hirose D, Takahashi K, Hirata E, Kuroda K. Characterization and Application of Carboxylate-type zwitterions synthesized by one-step. Journal of Ionic Liquids. 2(1):100027, 2022.
2021
Kato Y, Uto T, Tanaka D, Ishibashi K, Kobayashi A, Hazawa M, Wong RW, Ninomiya K, Takahashi K, Hirata E*, Kuroda K*. Synthetic zwitterions as efficient non-permeable cryoprotectants. Communications Chemistry. 4:151, 2021. (*co-corresponding author)
Sharma G, Kato Y, Hachisu A, Ishibashi K, Ninomiya K, Takahashi K, Hirata E, Kuroda K. Synthesis of a cellulose dissolving liquid zwitterion from general and low-cost reagents. Cellulose. doi.org/10.1007/s10570-021-04185-y, 2021.
Kadokawa R, Fujie T, Sharma G, Ishibashi K, Ninomiya K, Takahashi K, Hirata E*, Kuroda K*. High loading of trimethylglycine promotes aqueous solubility of poorly water-soluble cisplatin. Scientific Reports. 11(1):9770, 2021. (*co-corresponding author)
2020
Kuroda K*, Komori T, Ishibashi K, Uto T, Kobayashi I, Kadokawa R, Kato Y, Ninomiya K, Takahashi K, Hirata E*. Non-aqueous, zwitterionic solvent as an alternative for dimethyl sulfoxide in the life sciences. Communications Chemistry. 3:163, 2020.
(*co-corresponding author)
Kondo N, Hikida M, Nakada M, Sakurai Y, Hirata E, Takeno S, Suzuki M. Glioma stem like cells can be targeted in Boron Neutron Capture Therapy with boronophenylalanine. Cancers. 12(10):3040, 2020.
Hirata E*, Ishibashi K, Kohsaka S, Shinjo K, Kojima S, Kondo Y, Mano H, Yano S, Kiyokawa E, Sahai E. The brain microenvironment induces DNMT1 suppression and indolence of metastatic cancer cells. iScience. 23(9):101480, 2020. (*corresponding author)
2019
Wang R, Yamada T, Arai S, Fukuda K, Taniguchi H, Tanimoto A, Nishiyama A, Takeuchi S, Yamashita K, Ohtsubo K, Matsui J, Onoda N, Hirata E, Taira S, Yano S. Distribution and activity of lenvatinib in brain tumor models of human anaplastic thyroid cancer cells in severe combined immune deficient mice. Molecular Cancer Therapeutics. 18(5):947-956, 2019.
Hirata E and Kiyokawa E. ERK activity imaging during migration of living cells in vitro and in vivo. International Journal of Molecular Sciences. 20(3):679, 2019.
2018
Hirata E*, Ichikawa T*, Horike S, Kiyokawa E. Active K-RAS induces the coherent rotation of epithelial cells: A model for collective cell invasion in vitro. Cancer Science. 109(12):4045-4055, 2018. (*co-first author)
2017
Hirata E*, and Sahai E*. Tumor Microenvironment and Differential Responses to Therapy. Cold Spring Harbor Perspectives in Medicine. 7(7):a026781, 2017. (*co-corresponding author)
2016
Hirata E* and Kiyokawa E*. Future Perspective of Single-Molecule FRET Biosensors and Intravital FRET Microscopy. Biophysical Journal. 111(6):1103-11, 2016. (*co-corresponding author)
Seifert H*, Hirata E*, Gore M, Khabra K, Messiou C, Larkin J, Sahai E. Extrinsic factors can mediate resistance to BRAF inhibition in CNS melanoma metastases. Pigment Cell & Melanoma Research. 29(1):92-100, 2016. (*co-first author)
2015
Hirata E, Girotti MR, Viros A, Hooper S, Spencer-Dene B, Matsuda M, Larkin J, Marais R and Sahai E. Intravital imaging reveals how BRAF inhibition generates drug tolerant microenvironments with high integrinβ1/FAK signaling. Cancer Cell. 27(4):574-88, 2015.
~ 2014
Hirata E, Park D, Sahai E. Retrograde flow of cadherins in collective cell migration. Nature Cell Biology. 16(7):621-3 2014.
Yukinaga H, Shionyu C, Hirata E, Ui-Tei K, Nagashima T, Kondo S, Okada M and Matsuda M. Fluctuation of Rac1 activity causes biological and transcriptional heterogeneity of glioma cells. Journal of Cell Science. 15:1805-15. 2014.
Hirata E, Yukinaga H, Kamioka Y, Arakawa Y, Miyamoto S, Okada T, Sahai E, and Matsuda M. In vivo fluorescence resonance energy transfer imaging reveals differential activation of Rho-family GTPases in glioblastoma cell invasion. Journal of Cell Science. 125:858-68. 2012.
Kamioka Y, Sumiyama K, Mizuno R, Sakai Y, Hirata E, Kiyokawa E, Matsuda M. Live imaging of protein kinase activities in transgenic mice expressing FRET biosensors. Cell Structure and Function. 37(1):65-73. 2012.
Aoki K, Komatsu N, Hirata E, Kamioka Y, Matsuda M. Stable expression of FRET biosensors: a new light in cancer research. Cancer Science. 103(4):614-9. 2012.
Hirata E, Arakawa Y, Shirahata M, Yamaguchi M, Kishi Y, Okada T, Takahashi JA, Matsuda M, and Hashimoto N. Endogenous tenascin-C enhances glioblastoma invasion with reactive change of the surrounding brain tissue. Cancer Science. 100:1451-1459, 2009.
Hirata E*, Higashi T, Iwamuro Y, Watanabe Y, Ando M, Arakawa Y, and Nakahara I. Angioplasty and stent deployment in acute sinus thrombosis following endovascular treatment of dural arteriovenous fistulae. Journal of Clinical Neuroscience. 16:725-727, 2009.
(*corresponding author)
Iwamuro Y, Nakahara I, Higashi T, Iwaasa M, Watanabe Y, Hirata E, Tsunetoshi K, Taha M. Tentorial dural arteriovenous fistula presenting symptoms due to mass effect on the dilated draining vein: case report. Surgical Neurology. 65:511-515, 2006.